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Myelin-reactive T cells from patients with multiple sclerosis produce cytokines more consistent with a Th1-mediated response, whereas myelin-reactive T cells from healthy persons are more likely ...

Hans Lassmann, Hartmut Wekerle, in McAlpine's Multiple Sclerosis (Fourth Edition), 2006. CONCLUSION. Taken together, the pathology of multiple sclerosis consists of two essentially different features – the focal demyelinated plaque and the diffuse global brain injury. Both types of pathology occur on the background of an inflammatory response, …

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MS is diagnosed by MRI with a contrast medium to detect the presence of active plaques on the brain. It will also reveal inactive lesions that may not be associated with the …

Multiple sclerosis (MS) is the most common immune-mediated inflammatory demyelinating disease of the central nervous system. MS is characterized pathologically by multifocal areas of demyelination with loss of oligodendrocytes and astroglial scarring. Axonal injury is also a prominent pathologic feature, especially in the later stages.

Myelin-reactive T cells from patients with multiple sclerosis produce cytokines more consistent with a Th1-mediated response, whereas myelin-reactive T cells from healthy …

Multiple sclerosis (MS) is the most common immune-mediated inflammatory demyelinating disease of the central nervous system. MS is characterized pathologically …

What Causes an MS Plaque? September 11, 2012. The typical MS plaque seen in patients who have died early in their illness or who have had brain biopsies is composed of a mixture of lymphocytes with many more macrophages, without antibody. The macro-phages in the plaque contain myelin within their cell bodies in various stages of …

MR imaging has been formally included in the diagnostic work-up of patients who present with a clinically isolated syndrome suggestive of MS, and ad hoc diagnostic …

Pruritis (itching) is a form of dysesthesias and may occur as a symptom of MS. It is one of the family of abnormal sensations — such as "pins and needles" and burning, stabbing, or tearing pains — which may be experienced by people with MS. These sensations are known as dysesthesias, and they are neurologic in origin.

Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. In this disorder, your immune system attacks the myelin sheath or the cells that produce and maintain it. This attack causes inflammation and injury to the nerve sheath and ultimately to the nerve fibers that it surrounds. The process can result …

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Inflammatory demyelination happens when the body's immune system attacks myelin. Types of demyelination like MS, optic neuritis, and acute-disseminated encephalomyelitis are caused by ...

Owing to its ability to depict the pathologic features of multiple sclerosis (MS) in exquisite detail, conventional magnetic resonance (MR) imaging has become an established tool in the diagnosis of this disease and in monitoring its evolution. MR imaging has been formally included in the diagnostic work-up of patients who present with a …

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The pathologic hallmark of multiple sclerosis is multiple focal areas of myelin loss within the CNS called plaques or lesions, accompanied by variable gliosis and inflammation and …

The diagnosis of multiple sclerosis requires the constellation of clinical findings and various investigations (see McDonald diagnostic criteria for multiple …

Multiple sclerosis (MS) is a long-lasting (chronic) disease of the central nervous system. It is thought to be an autoimmune disorder, a condition in which the body attacks itself by mistake. MS is an unpredictable disease that affects people differently. Some people with MS may have only mild symptoms. Others may lose their ability to see ...

An MS lesion, sometimes also called a plaque or scar, is an area in the central nervous system that has been damaged by the immune system's attack. Lesions are thought to occur upon a backdrop ...

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Multiple sclerosis (MS) is a complex neurodegenerative disease affecting the central nervous system (CNS). The onset of MS has been typically observed in individuals aged from 20 to 40-years, with the to male ratio of 1:2. MS appears as abrupt onset of focal sensory disturbances that is accompanied by unilateral painless …

Multiple sclerosis--the plaque and its pathogenesis. Multiple sclerosis--the plaque and its pathogenesis. Multiple sclerosis--the plaque and its pathogenesis N Engl J Med. 2006 Mar 2;354(9):942-55. doi: 10.1056/NEJMra052130. Authors Elliot M Frohman 1, Michael K Racke, Cedric S Raine. Affiliation 1 Department ...

Multiple sclerosis (MS) is characterized by disseminated patches of demyelination in the brain and spinal cord. Common symptoms include visual and oculomotor abnormalities, paresthesias, weakness, spasticity, urinary dysfunction, and mild cognitive symptoms. Typically, neurologic deficits are multiple, with remissions and exacerbations ...

If you have multiple sclerosis (MS), overactive immune cells in your body trigger inflammation that damages myelin. When that happens, damaged areas known as plaques or lesions form on the brain ...

Changes can occur at any time — even as a first symptom of MS — but are more common later in the disease. Cognitive function is related to the number of lesions and the location of the lesions on the brain, as well as brain atrophy. Cognitive dysfunction can occur with any disease course, but is slightly more likely in progressive MS.

Multiple sclerosis (MS) is a chronic complex neurodegenerative disease, targeting the central nervous system (CNS) and widely believed to be autoimmune in …

There are four types of multiple sclerosis: Clinically isolated syndrome (CIS): When someone has a first episode of MS symptoms, healthcare providers often categorize it as …

Exactly why these seizures occur more often in people with MS isn't completely understood.MS lesions in certain areas of the brain might trigger these seizures. However, lesions are very common in MS, and seizures are unusual, so there are probably other factors that play a role in seizures, too.. Seizures may be the first noticeable sign of MS …

INTRODUCTION. The pathologic hallmark of multiple sclerosis (MS) is multiple focal areas of myelin loss within the CNS called plaques or lesions (Figure 1-1 A–C).1,2 Demyelination is accompanied by variable gliosis and inflammation and by relative axonal preservation (Figure 1-1 D–I).Lesions are disseminated throughout the CNS but have a …